Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed

Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed

Friday, March 2, 2012

The American Cancer Society estimates that 44,000 new cases of pancreatic cancer will be diagnosed this year and that 37,000 people will die from the disease. These are not strong odds. A new drug, rigosertib, allows pancreatic cancer cells to rush through replication ? and then stops them cold, killing them in in the middle of a step called M phase. Healthy cells that don't rush are unharmed.

Data from a phase I clinical trial of patients with advanced pancreatic cancer and additional solid tumors recently published in the journal Clinical Cancer Research shows the strategy has promise. While the goal of any phase I trial is to establish the dosage that best balances effectiveness against side effects, 11 of the 19 patients treated achieved stable disease, which lasted for a median of 113 days.

"Really, the drug takes one of cancer's greatest strengths and turns it into a weakness," says Wells Messersmith, MD, co-leader of the Developmental Therapeutics Program at the University of Colorado Cancer Center and the clinical trial's national principal investigator.

Instead of going with the flow of the natural cell cycle, cancer cells amplify two signals ? PLK1 and PI3K ? which allows them to blast through the cell cycle and divide much more quickly. In the process, they break this step of the natural cell cycle, known as the G1 regulatory mechanism, and thus depend on the kick of PLK1 and P13K to push at a frenzied pace through replication.

It's specifically these two signals, PLK1 and PI3K, that rigosertib targets. With these signals turned off, cancer cells get stuck and die in the stage of the cell cycle called M phase ? while healthy cells that stuck to the slower, natural method of division chug past unharmed.

Wells Messersmith, MD, co-leader of the Developmental Therapeutics Program at the University of Colorado Cancer Center

"This one-two punch, targeting these two distinct signaling pathways, allows us to interfere twice with cancer cells' ability to replicate," Messersmith says. And it also allows doctors to target cancers that may have evolved resistance to one or the other target.

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University of Colorado Denver: http://www.ucdenver.edu

Thanks to University of Colorado Denver for this article.

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Source: http://www.labspaces.net/118110/Tortoise_and_the_hare__New_drug_stops_rushing_cancer_cells__slow_and_steady_healthy_cells_unharmed

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What you ought to Know About Medical health insurance ...

Having a dependable health insurance coverage contributes a great deal towards a person's sense of protection.

As an person, you are aware that you should take care of your health so you employ ways and make an effort to guide a healthy lifestyle.

In spite if this, you will find unexpected conditions regarding your lpr reflux symptoms that no matter how hard you try to prevent, tend to be rather unavoidable.

Thus, you have to make sure that you have a reliable insurance plan and sufficient coverage in the event you need to use them in the future, or should an emergency ensue.

Essentially, health insurance coverage is divided into two categories: private and government-sponsored.

This really is further broken down into several types:

-- Private health insurance

This is a non-government health insurance coverage that is paid for by an individual.

-- Employment-based plans

This particular health insurance plan's offered by the company that you work with. You may also make the most of being a dependent for a relative's health insurance coverage which includes one's immediate family.

-- Directly-purchased insurance plans

If you think that the coverage provided by the government or your company is not enough, you may purchase a separate plan that you can purchase privately.

-- Government-sponsored health insurance deals

These are plans funded through the federal government. There are several levels, ranging from local, state to federal coverage.

This particular health insurance plan's required by regulation and has several types:

One. Medicare

This can be a health insurance plan which is provided on a national level. The folks who can get Medicare benefits are those who are above 65. They may also be given to individuals with certain afflictions.

2. Condition Children's Medical health insurance Program

This can be a program administered by the state. It may have a different reputation for each state, but the definitive goal of this plan is to offer health care to children whose parents cannot provide for them.

3. State medicaid programs

This is a health insurance package which is also offered by their state. This healthcare aid, as the name implies, may be known differently within other states. The basic principle, however, is to offer health insurance benefits for the needy.

4. Military and veteran healthcare

There are several healthcare benefits and insurance plans which are provided for upon the market or energetic members from the military. These types of plans extend to their immediate families and their heirs.

Also, the actual Department of Veteran Matters offer health insurance coverage to veterans and their dependents.

5. Indian native Health Support

Health insurance plans are also agreed to eligible United states Indians.

Here are some tips how you can get the best offer out of the very costly health insurance deals that are available nowadays:

- If you're self-employed, look for a organization that offers an extensive fibroids symptom insurance coverage, and at the same time would not make a big dent in your pocket. Keep in mind that spending a day or two in the hospital can be very costly, so ensure that you have ample coverage.

- Discover everything concerning the health insurance plan that you have. If you bought it privately, if it is part of your employee benefits or it is a coverage sponsored through the federal or state government, it is best to be aware of your own rights to a suitable what is eczema coverage.

Healthcare is a very essential requirement in every person's everyday life and you should ensure that you are secure and never lacking in this division.

Source: http://www.chameleoncafesf.com/blog/what-you-ought-to-know-about-medical-health-insurance

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Report: Global Prefab Market Bright | Daily Business News

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> Economy, Factory-Built Homes > Report: Global Prefab Market Bright

According to a new report, present day mobile homes are increasingly being considered permanent dwellings for the middle-income individuals, in many parts of the world, and the sector contributes significant revenues to the entire housing industry. The Manufactured Homes segment within the prefabricated housing market, is the most competitive category in the overall housing industry, and accounts for around 10 percent of the single-housing starts in the US. Shipments of manufactured homes witnessed an increase in 2011, a sharp relief to the slump witnessed in previous years. Also according to the report, with the trend of housing communities taking root, the market for larger and expensive-to-maintain homes is on a steady phase of decline, translating into growing demand for manufactured homes. However, despite the bright prospects, lack of retail financing is the greatest challenge confronting the manufactured homes segment. Australian and New Zealand markets are considered pioneers in the factory built housing concept. In the future, the report predicts rapid development from newer and burgeoning markets of China, India, Taiwan, Korea and others is slated to place Asia-Pacific on the fast track, compelling a strong compounded growth rate of 4.4 percent through 2017. By product segment, strong gains are expected from Panelized Homes segment, while manufactured homes segment retains lead as the single largest prefabricated housing market.

(Image Credit:?Joe Mabel via Wikimedia Commons)

Source: http://www.mhmarketingsalesmanagement.com/blogs/daily-business-news/report-global-prefab-market-bright/

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Making Life Insurance Work For Your Needs | Pietermaritzburg.com

We at Pietermaritzburg.com strive to bring you the very best and accurate information collected about our fair city. The site is updated by the owners but the listings are placed by its residents. We hope you enjoy reading the information as much as we enjoyed presenting it to you.

Source: http://www.pietermaritzburg.com/making-life-insurance-work-for-your-needs/

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Currency Trading Tips And Tricks From The Top Experts | Investing ...

There are business opportunities that are surely better than others, and there are also financial markets that are larger than others. The forex market is the largest trading platform for currency in the world. The tips below can help you decide if Forex trading is the right strategy for you.

If you work at it, you can make a lot of money. When you win on trades, remember to lodge a withdrawal order. The point of Forex is to make some money, so when you do, treat yourself!

It is not wise to repeat your position every time you open up a trade. Opening in the same position each time may cost forex traders money or cause them to gamble too much. Vary your position depending on the trades above you if you want to be profitable in the market.

This is an advantage of forex versus other markets. Forex is a 24 hour operation, and you can place trades at all hours. With forex, you only need a small amount of capital to take advantage of many opportunities. The Forex market being global is open and available to everyone 24 hours a day.

If used incorrectly, Forex bots are just programs that will help you lose money faster. This may help the sellers, but it will not help the buyers. Don?t use Forex robots or any other product that claims wild profits. Instead, rely on your brainpower and hard work.

Learning and progress come slowly. Don?t overdo it. Otherwise, you?ll lose everything you invested pretty quickly.

Unless you can pin down a motivation for your action, it?s probably too dangerous for you to take that action. Your broker can provide advice and help to talk you through the potential issues which may come up.

Identify the flaws in the software you use for trading. Even if a software program has been selling in the market for a while, it can?t be perfect. Be prepared for the glitches that are inherent in your software and learn the workarounds. You need to know in case you run into a problem when trading.

You?ve made the decision to start Forex trading. Before you start doing anything in forex, make sure you understand the basic fundamentals of how currency exchange markets function. Learn about currency fluctuations, and what causes shifts in the currency markets. Research the various foreign currencies that are traded on the forex market. With a good amount of research, your success rate will tremendously improve when you are more aware of which currencies will develop the most profit in the long run.

Now, you need to understand that trading with Forex is going to require a lot of effort on your part. Just because you?re not selling something per se doesn?t mean you get an easy ride. Just remember to focus on the tips you?ve learned above, and apply them wherever necessary in order to succeed.

Cookie tins are an impressive way to store your souvenirs! You might want to look at these articles on tins.

Source: http://invetingmarketanalysis.com/2012/02/29/currency-trading-tips-and-tricks-from-the-top-experts/

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Chicken slaughter art project ruffles feathers (omg!)

LAWRENCE, Kan. (AP) ? Officials have banned an artist from publicly slaughtering chickens in eastern Kansas, saying the proposed art installation would amount to animal cruelty.

Lawrence's Assistant City Attorney Chad Sublet said Tuesday that artist Amber Hansen told him she "intends to abide by the city ordinance." Violating the animal cruelty ordinance could lead to a fine of up to $1,000 and six months in jail. Even keeping the chickens on private land would require her to meet other city codes on animal care.

Sublet said Hansen is considering alternatives to draw attention to the process of slaughtering animals, including a public sculpture.

Through the project, called "The Story of Chickens: A Revolution," Hansen originally planned to display coops of chickens at locations across Lawrence, where they would be cared for by volunteers. The birds would later be publicly slaughtered by a local farmer and served as a meal.

"By building a relationship with the birds, the project will transform the contemporary view of chickens as merely 'livestock' to the beautiful and unique creatures they are, while promoting alternative and healthy processes of caring for them," Hansen, an artist in residence at the University of Kansas, wrote on her project's website.

She received funding from the Andy Warhol Foundation for Visual Arts' Rocket Grants program in collaboration with the Charlotte Street Foundation and the University of Kansas' Spencer Museum of Art.

Hansen spoke to the Lawrence-Journal World but didn't immediately respond to a message from The Associated Press left for her through a relative. She has said she grew up on a farm where some animals were raised for food. She said she began to feel disconnected from her food after she left and went to art school.

"If people choose to eat meat, it is an important process to witness and be mindful of," Hansen told the Lawrence newspaper. "It is a process that takes place on a mass scale every day, and we aren't really allowed to see it."

But several animal rights activists, including Lawrence's Compassion for All Animals group and United Poultry Concerns, had expressed concerns, including that the public display would be stressful for the animals. Hansen acknowledged there had been concerns.

"The project will move forward to accommodate that discussion, but it will abide by the city's codes," she told the Lawrence newspaper.

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Online:

The Story of Chickens: http://thestoryofchickens.wordpress.com/2012/01/01/hello-world/

___

Information from: Lawrence Journal-World, http://www.ljworld.com

Source: http://us.rd.yahoo.com/dailynews/rss/entertainment/*http%3A//us.rd.yahoo.com/dailynews/external/omg_rss/rss_omg_en/news_chicken_slaughter_art_project_ruffles_feathers163043586/44669294/*http%3A//omg.yahoo.com/news/chicken-slaughter-art-project-ruffles-feathers-163043586.html

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New Port of Entry in Northern Cypress ... - Blue Water Sailing

Karpaz Gate Marina, part of the all-new Karpaz Bay Resort in Northern Cyprus, is now an official Port of Entry. All marine vessels can now officially enter Northern Cyprus at Karpaz Gate Marina following the recent approval of Port of Entry status at the beginning of February. As a result, visitors to the marina will now experience a smooth arrival to, and departure from, Northern Cyprus via Karpaz Gate Marina, which is positioned in a protected bay on the north side of the Karpaz Peninsula at N35? 33,5? ? E034? 13,6?.

With 300 berths, 12 of which are designed for super yachts up to 180 feet, Karpaz Gate Marina provides much-needed berthing capacity within the Mediterranean. Since its soft-launch in June 2011, many hundreds of yacht owners, passengers and crew, traveling from all over the world, have been welcomed by the Karpaz Gate Marina team.

Itay Singer, of Sea-Alliance Group, the marina management company, said, ?Becoming an official port of entry to Northern Cyprus is a great coup for us and all our visitors. We can now provide smooth access into and out of the marina, with no need for visiting yachts to visit other ports before coming to, or leaving, Karpaz Gate Marina. The move helps to put Karpaz on the map as an international yachting destination.?

Karpaz Gate Marina is a five star marina and resort, where visitors will now be able to enjoy duty-free shopping and fuel, also as a result of the recently confirmed Port of Entry status. Additional services are provided in the expansive 59,000 square foot dry dock including a 300 ton travel lift which can service vessels of up to 32 foot beam, 13 foot draft and more than 147 foot length, including mono- and multi-hulls.

Leisure services include a restaurant, terrace and bar at Hemingway?s Restobar, which serves freshly prepared local and international dishes. There is also The Market, selling branded and local produce, a Fitness gym with high quality equipment, and an exciting children?s play area. In the summer, a luxury Pool and Beach Club will also be completed, which will feature a 115 foot swimming pool.

Further details regarding check-in formalities can be obtained via the Reception at Karpaz Gate Marina or at www.karpazbay.com.

Courtesy of www.noonsite.com.

Source: http://bwsailing.com/mq/2012/02/29/new-port-of-entry-in-northern-cypress/

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